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This may be explained by the findings of Albares and colleagues, Guinot and colleagues, and Kang and colleagues , who reported that pregnancy, use of hormonal contraception and lack of use of sunscreen are aggravating factors of melasma due to increase number and activity of melanocyte in epidermis

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P = .026)

It's important for the oncology team to know when patients are starting these agents because many of them have gastrointestinal [adverse] effects, which might be confused with an exacerbation of carcinoid syndrome, which is seen in [patients with] neuroendocrine tumors, which might lead to an increase in the therapy for neuroendocrine tumors, which would not be appropriate

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