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doi: 10.1111/j.1742-4658.2008.06632.x 37

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Subcutaneous tissue is densely populated with mast cells, and cationic peptides are established activators of the MRGPRX2 receptor on human skin mast cells, triggering degranulation and histamine release through a signalling cascade that has been characterised in some detail in primary human skin mast cells

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