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Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging

Since the discovered variants are not pathogenic, this emphasizes the role of benign variants in predisposing to HCC

For example, preclinical in vivo studies performed by Boban-Blagic et al

Given the significant variability of the manifestations, an elevated degree of suspicion and clues in the family history are needed to detect these pathologies in the adult population

It does not yet have large-scale human clinical trial results