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Why This Matters The dose-dependent distinction highlights an important clinical insight: For obesity management, the upper dose range (812 mg) is likely to dominate

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If you are past the initial phase, have reached your target weight or a stable maintenance phase, and want to reduce frequency, discuss it with your provider

Notably, based on the results from part 1 of the ESSENCE trial, on 15 August 2025, the FDA approved semaglutide 2.4 mg for the treatment of adults with MASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis)

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