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Although preclinical studies link GLP-1 signaling to brown adipose tissue (BAT) activation and adipose tissue browning, human data indicate that BAT mass and thermogenic capacity in adulthoodparticularly in obesityare limited, constraining the contribution of energy expenditure to sustained weight loss

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10.2337/diacare.28.5.1092 23 del CastilloE.MeierR.ChungM.KoestlerD

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