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Due to the decrease in GH secretion, the secretion of IGF-1, which is driven by GH release, was also drastically reduced

Most scientific peptides are stable in bacteriostatic water for injection, but some hydrophobic, copper-bound, or long-chain peptides require alternative solvents (sterile water, normal saline, or specific buffers)

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While STEP-HFpEF was underpowered to truly detect outcome differences, the difference observed supports the need for larger, outcomes-driven trials in obese patients with HFpEF