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In addition to regulating many aspects of growth and development, thyroid hormones are important for the migration, proliferation, and differentiation of specific neuronal populations, the overall architecture of the brains cortex, the formation of axonal connections, and the myelination of the central nervous system, which occurs both before and shortly after birth (reviewed in 20)

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While only 1417% of participants drop out of clinical trials, approximately 50% of individuals abandon their programs within the first year in everyday circumstances

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