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CuPT inhibits cancer cell growth by targeting active sites of 19S DUBs (UCHL5 and USP14), leading to accumulation of both total and K48-linked ubiquitinated proteins (e.g., CDKN1A, CDKN1B, BAX, and NFKBIA) and GFPu (a surrogate proteasome substrate) (Liu et al., 2014b)

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Isoliquiritigenin suppressed COX-2, CYP4A, PGE p-PI3K, p-PDK, and p-AKT, which led to its apoptotic and migration-reducing actions on MDA-MB-231 and BT-549 cells