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Phase 1a studies in healthy volunteers, published in Diabetes, Obesity and Metabolism in 2023, established the compound's single-dose and multiple-dose pharmacokinetics, confirming a half-life supportive of once-daily dosing, a favorable food-effect profile, and dose-proportional exposure across the tested range

1 These agents also delay gastric emptying and reduce appetite via central mechanisms, thereby contributing to their metabolic effects

Most cases are mild to moderate, though some patients may experience more significant symptoms

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