10.1038/nature13835 40 FeldmannM.MainiR
A short 1-week titration phase at 1 mg is often used to improve tolerance before increasing to the full 2 mg dosage Reconstitution Steps Using a sterile syringe, draw 3.0 mL bacteriostatic water
Ren W, Xia Y, Chen S, Wu G, Bazer FW, Zhou B, et al
Zubair M, et al
Beyond, a range of factors contribute to the complex process of VSMCs calcification, including imbalances in the regulation of calcium and phosphate levels, cell death (apoptosis, ferroptosis), diminished presence of calcification inhibitors, the release of vesicles containing mineral-forming components (mineralizing matrix vesicles or MVs), and crosstalk between VSMCs and VECs (1012)
The Clinical Decision: DIY vs