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Methods Cell Biol 52 (8), 155176

2.13 SAMP8 mice and 5FAD mice insights in Alzheimers disease research The identification of mutations linked to familial AD has provided critical insights into the fundamental mechanisms underlying disease pathogenesis and progression

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Moreover, there is a strong association between the level of soluble oligomeric A, and the severity of synaptic loss and cognitive dysfunction in AD when compared to their fibrillar counterpart (Lesne, 2014

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