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For example, in a 72-week clinical trial (61), a weekly dose of 15 mg of tirzepatide led to 21% total body weight loss compared with 3% in the placebo group receiving only a hypocaloric diet

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In a mouse model, central infusion of recombinant TNF- , when combined with sub-threshold noise exposure, synergistically promoted microglial activation, loss of parvalbumin-positive inhibitory neurons in the AC, and induced auditory processing deficits and tinnitus-like behaviors, which were not observed with either insult alone (Deng et al., 2020b)

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Some Kaiser plans may cover other forms of tirzepatide, such as Mounjaro