Exercise and cold exposure induce PGC-1 coactivators, amplifying ERR-dependent gene sets involved in fatty-acid uptake and -oxidation (for example, CPT1, MCAD), OXPHOS subunits, TCA cycle enzymes, and mitochondrial transcription factors (for example, TFAM)
Unlike benzodiazepines or other sedatives, it doesn't appear to create tolerance requiring escalating doses or produce withdrawal symptoms upon cessation
& Mashek, D
Good sleep supports metabolism and the repair of muscle tissue, making it a key component of any fat loss plan
Wu Q, Zhang Y, Zhang Y, Xia C, Lai Q, Dong Z, et al
Wasted money and lost momentum Beyond the biological risks, there is a practical cost