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Collectively, these results directly demonstrate that resistance-causing PfK13 mutations in early rings result in a 1.5-fold loss in PfK13 protein abundance, which decreases intra-parasitic heme levels and subsequently impairs peroxide antimalarial activation

If you are switching between weekly medications, you should not administer two medications in the same week

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doi: 10.1007/s00405-019-05558-7, 37