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Gut-Thyroid Axis and Microbiome Modulation The gut microbiome plays a critical role in shaping systemic immune responses, and alterations in microbial composition have been implicated in the development of AITD [40,41]

Individuals with a history of medullary thyroid cancer or Multiple Endocrine Neoplasia Type 2 should avoid semaglutide entirely, as GLP-1 agonists carry a theoretical increased risk of thyroid cell proliferation

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Looking ahead, the team plans to expand its data collection across more imaging centers to build stronger evidence for future national guidelines

Journal reference: Xie Y, Choi T, Al-Aly Z (2026)

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