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Half-life and dosing frequency are the primary differences

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Batch-to-batch variation of inputs can be managed by blending across multiple batches, which is practical at larger breweries

For example, metformin-treated T2DM patients with elevated levels of Bacteroides fragilis in the gastrointestinal tract, whose metabolite glycoursodeoxycholic acid (GUDCA) is involved in inhibiting FXR signaling (Sun et al., 2018)