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It is the first truly food-flexible oral GLP-1 approved for weight loss

However, for optimal results, its generally recommended to combine their use with a balanced diet and regular exercise

Activation of tubular epithelial cells in diabetic nephropathy

GLP-1 receptors are found in brain regions associated with reward and pleasure, so by modulating these pathways, semaglutide and tirzepatide may influence the rewarding aspects of food consumption

What is the evidence that these drugs are worth it long term

One of the reasons for its success was because it provided better control of blood glucose levels than previous treatments