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While tirzepatide is a dual-action medication (targeting GLP-1 and GIP), semaglutide mimics one hormone, GLP-1, which regulates appetite, slows digestion, and triggers insulin release

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Specific interaction of both roGFPs with glutaredoxin in vitro strongly suggests that in situ both variants preferentially act as sensors for the glutathione redox potential

This can lead to complications such as fetal growth restriction, preterm birth and even stillbirth

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