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Things like age, weight , what you eat, how well you sleep, and your lifestyle can change how well your body takes in and uses glutathione

Chen B, Liu Y, He Y, et al

9 GSH can be depleted intracellularly either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate) via inhibition of synthesis, or by subjecting cells to oxidant stress