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In an experimental model of cognitive impairment induced by scopolamine, the beneficial effect of canagliflozin on cognitive function has been attributed to the capacity to inhibit acetylcholinesterase and increase acetylcholine M1 receptor expression (Arafa et al., 2017)

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Other Considerations Physical Challenges : Loose skin can interfere with physical activities, leading to reduced mobility, skin irritation, and difficulty maintaining hygiene in areas like skin folds

Patients who reach the maintenance phase and sustain it over 24 to 36 weeks have reported total body weight reductions ranging from 15% to upwards of 24% in some cases

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