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This strategic design allows researchers to fully engage the GIP pathway for enhanced metabolic effects while minimizing the dose-limiting gastrointestinal tolerability issues common with high-dose GLP-1 agonism, making it uniquely valuable for studying synergistic incretin mechanisms

Alcaide-Aldeano, A., Garay, A., Alcoberro, L., Jimnez-Marrero, S., Yun, S., Tajes, M., et al

Endocr Rev 26(7):916943

Peak plasma concentrations (C max ), time to C max (t max ) and area under the plasma concentration versus time curve for the last measurable plasma concentration (AUC 0last ) were calculated using noncompartmental methods

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