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The STEP program (Semaglutide Treatment Effect in People with obesity) showed participants receiving semaglutide lost between 10% and 22% of their body weight depending on dose, compared to 2.4% in the placebo group

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Another paper by the same group showed that incubation of HCAECs with exendin-4 resulted in a dose-dependent up-regulation of DNA synthesis which was associated with enhanced eNOS and Akt expression [106]