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This small molecule compound was developed through sophisticated structure-guided design and binding calculations as part of a systematic effort to create membrane-permeable NNMT inhibitors with enhanced potency and selectivity

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2.2 Participants In the single-dose trial, eligible subjects were healthy males, aged 1850 years with a body weight of 65.095.0 kg and a body mass index (BMI) of 18.527.5 kg/m 2

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The novel biguanide MC001 showed much stronger antitumor effect and relatively weaker proglycolytic activity compared with metformin as shown in vitro in colorectal cancer cells ( in vitro by modulating the AMPK-mTOR and androgen receptor signaling pathways (Kim et al., 2023)

J Crohns Colitis 2021