Wet skin dilutes the product and reduces absorption
Copper Peptide Products Versus Retinoids and Cosmetic Actives Cu-GHK has been compared with vitamin C and retinoic acid in a small collagen-production context summarized in a topical peptide review, where collagen increased in 70% of Cu-GHK-treated participants versus 50% with vitamin C and 40% with retinoic acid after one month [2]
[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Jones DP
Skin Rejuvenation In the 12-week comparative trial, 70% of women showed increased collagen with GHK-Cu versus 50% with vitamin C versus 40% with retinoic acid (Pickart et al., 2015)
There are several lines of evidence correlating the depletion of intracellular glutathione with generation of ROS/RNS and progression of apoptosis in SLE patients [50,61,78]
Subcutaneous injection delivers GHK-Cu systemically, which makes more sense for wound healing and skin remodeling protocols