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1 GLP-1 agonists such as semaglutide are known to be highly effective in weight loss in both diabetic and non-diabetic patients

Side Effects Gastrointestinal symptoms: Most common adverse effects were mild-to-moderate nausea, vomiting, and diarrhea, occurring primarily during dose escalation [6] [12]

No head-to-head trials have yet been conducted to directly compare their efficacy or safety

The glucagon receptor component is hypothesised to increase energy expenditure and promote fat breakdown (lipolysis), potentially contributing to the substantial weight loss observed in early-phase trials

Semaglutide and orforglipron are pure GLP-1 agonists

however, the risk is increased when used alongside insulin or sulfonylureas