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However, that doesnt quite fit with the availability of food over the century, the abundance of tasty cakes and pies, and the prior consumption of sugar (which has fallen since the 90s) and butter

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In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]

doi: 10.1016/j.jpeds.2014.09.019 30 De LenDDLiCDelsonMIMatschiskyFMStanleyCAStoffersDA