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CL and DW performed recombinant expression and purification of GST proteins

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The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)

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Laboratory studies have extensively characterized glutathione's role in phase II metabolism, where it conjugates with reactive drug metabolites and environmental toxicants via glutathione S-transferases, a pathway central to pharmacology and toxicology research