sglt2 vs glp 1 SGLT2i and GLP-1 RA therapy in type diabetes and reno-vascular outcomes: a real-world study | Diabetologia GLP-1 Agonists vs. SGLT2 Inhibitors:

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The interplay between CoQ redox balance, AMPK activation and ETC directionality suggests that the ferroptotic outcome of complex I inhibition depends not only on its biochemical activity but also on the metabolic state of the cell

In one sentence, the mechanism is receptor-mediated: GHRP binding to GHS-R1a activates a Gq/11-coupled phospholipase C cascade that mobilises intracellular calcium and triggers exocytosis of stored GH from the anterior pituitary, independent of hypothalamic GHRH signalling