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For PCOS patients with normal or low weight, blind extrapolation should be avoided due to the lack of evidence and the higher potential risks associated with further weight loss

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In humans suffering from obesity, daily systemic injections of liraglutide did not ameliorate OA-related pain, probably because of poor access and hence poor local concentrations of liraglutide in the knee joint 44

However, in humans, these relationships remain predominantly inferential and require confirmation through longitudinal and mechanistically designed studies incorporating direct metabolomic measurements

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