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Researchers now think that polyphenolic substances work at the molecular level to improve endothelial function and lower platelet aggregation because they can stop blood clots, reduce inflammation, and stop platelets from sticking together (401)

But what are the adverse effects

SIRT1 is widely expressed across tissues and organs such as the brain, heart, liver, kidneys, and skeletal muscle, with particularly high expression in tissues vulnerable to oxidative stress and those with high metabolic activity

Common signs include: Fatigue Weakness Anemia Pale or yellowish skin Numbness or tingling in the hands and feet Difficulty with balance Glossitis (a swollen, red tongue) Memory or concentration difficulties If you suspect you may have a vitamin B12 deficiency, consult your healthcare provider for appropriate testing and personalized recommendations

doi: 10.1002/iub.2067 118 VidelaLAVargasRValenzuelaRMuozPCorbariAHernandez-RodasMC