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In addition, Ex-4 provides neuroprotection against ischemia-induced damage in the hippocampus by downregulating hypoxia-inducible factor-1 and modulating apoptosis through the increased B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X-protein (Bax) ratio, which is mediated by the GLP-1 receptor [48]
Ross, professor and medical director at the Henry Ford College Paramedic Program and Medical Director for Trauma Services at Bothwell Regional Health Center, explained what happens if someone takes too much Ozempic, Wegovy or another GLP-1 agonist drug, noting that the most common symptoms are nausea, vomiting, and occasionally diarrhea. Usually, this resolves on its own, but in large overdoses, the symptoms can be persistent causing patients to become severely dehydrated requiring IV fluids and anti-nausea medication, Dr