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Another use of GLP-1RA is also under study in ELAD (121), a phase II b clinical trial to provide strong evidence in using GLP-1RA as neuroprotective agents against Alzheimers Disease

At the same time, preserving lean muscle mass during rapid weight loss remains important

However, the safety and efficacy of this potent new agent in the vulnerable population with comorbid CKD remain largely unexplored

PIONEER 1: Randomized Clinical Trial Comparing the Efficacy and Safety of Oral Semaglutide Monotherapy With Placebo in Patients With Type 2 Diabetes

GLP-1 medications have gained attention for their effectiveness in supporting weight loss

These results are based on studies of branded medications in people without diabetes with BMI 30, or BMI 27 plus a weight-related condition when paired with diet and exercise changes