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Some people naturally have more responsive GLP-1 receptors in their hypothalamus, leading to earlier and more pronounced appetite suppression

Conversely, depression can undermine self-care behaviors that are necessary for effective diabetes management, such as regular medication adherence, appropriate dietary choices, and consistent physical activity [30, 33]

This work was supported by the National Institute on Drug Abuse Intramural Research Program (M.F., G.R.M., M.N.N., V.M., O.A.A., M.A.H., and L.L.) and the National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research (M.F., G.R.M., V.M., and L.L.)

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These effects are typically mild and transient as the body adjusts to the medication