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IBM is characterized by primary pathological hallmarks, including protein amyloid aggregates in muscle fibers, inflammation, and loss of skeletal muscle 114,251

Quick Take (TLDR) Mostly animal and in vitro data plus multiple very small uncontrolled human reports (knee pain case series n=16, interstitial cystitis pilot n=12, 2subject IV infusion) and no randomized controlled trials or published human pharmacokinetic profiles

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Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline