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Data obtained by the AVANT trial of adjuvant bevacizumab in colorectal cancer shows evidence of higher incidence of relapses and deaths in bevacizumab treated patients due to disease progression suggesting an increased tumor aggressiveness after anti-angiogenic therapy [288]
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It is recognized for its potent and selective inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme implicated in a variety of metabolic and oncogenic processes
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