Furthermore, TPOAb-positive women, even in euthyroid states, have been found to exhibit increased oxidative stress markers, suggesting that oxidative damage may precede overt hypothyroidism and impair pregnancy adaptation mechanisms [90, 91]
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Analogously, activation of the KDEL receptor (KDELR) by cargo from the endoplasmic reticulum (ER) was shown to trigger signal cascades via Gs and Gq/11, with KDELR acting as a non-canonical GPCR at the Golgi 4
