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Attempting to use an opened pen beyond 28 days compromises both safety and treatment efficacy, making replacement necessary

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BPC 157 antagonized the general anaesthetic potency of thiopental and reduced prolongation of anaesthesia induced by L-NAME/thiopental combination

We can think of two possible reasons: One is that primary care, general practice (GP) veterinarians, either not having ultrasound devices or not being sufficiently trained to use them for echocardiography, might have complained that the EPIC Study's requirement of having echocardiograms was discriminatory against them and in favor of the cardiologists