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JCI Insight 6, e151621

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Tier 1 is the least-expensive option and Tier 5 is the most expensive

This digestive side effect typically emerges within the first two weeks and improves substantially for most people within 4-8 weeks as the body acclimates to the medication

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medRxiv 2026, IQVIA PharMetrics cohort (n=20,504 non-diabetic weight-loss users), incident allodynia 35 vs 15 per 1,000 person-years against bupropion-naltrexone, adjusted HR 2.15 (95% CI 1.572.96)