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2015;10:e0118436

As a large protein (approximately 27 kDa), it cannot be synthesized by peptide compounding methods and requires either gene therapy delivery or cell-based manufacturing

The route of administration changes the profile significantly in terms of absorption and risk

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Strong oxidants such as hydrogen peroxide (H 2 O 2 ) instead readily modify protein thiols beyond reversible redox states, to form sulfinic (-SO 2 H) and sulfonic acids (-SO 3 H), thus preventing conversion into the disulfide-linked pathological species dsNNTTR