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Seek medical advice for severe or persistent diarrhoea lasting more than a few days, signs of dehydration, severe abdominal pain, blood in stools, or symptoms of pancreatitis

Females taking spironolactone may experience menstrual irregularity, including postmenopausal bleeding, breast tenderness or mastalgia, hirsutism, deepened voice, and amenorrhea

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PLoS ONE 8 , 72967 (2013)

A recent study revealed that ambient Mn concentration was associated with thinner grey matter thickness in men, suggesting cortical atrophy (Woo et al., 2023)

The same labeled dose of silymarin can produce very different blood levels depending on how it is formulated