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The 12 mg dose achieves 24.2 % weight reduction over 48 weeks in obese patients, the highest recorded effect in the incretin class

Key Points GLP-1 medications work by reducing hunger, which leads to weight loss

Metabolic impact : The mechanisms by which these medications improve insulin secretion, suppress glucagon, delay gastric emptying, and reduce appetite are all dose-related

Obesity 2014

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Future studies incorporating biochemical collagen assays, protein-based analyses, and high-resolution histomorphometric quantification will be required to definitively establish fibrosis resolution