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Aggressive handling, the wrong pH, or bacterial contamination can denature them, rendering them completely useless

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And critically, it needs to be effective at very low doses because even with skin-penetration enhancers, you're rarely getting more than a few milligrams across in 24 hours

doi: 10.1186/1753-2000-6-25.

But when you look at a study where gymnasts and pole vaulters have six extra years on the cyclists and the cyclists only have two extra years on the general population, Im like, Huh, what? Its not all about the cardiorespiratory fitness