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serious hypersensitivity reactions have been reported with this drug

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While no effect was observed across the entire study cohort, stratification into occasional and regular meat-eaters revealed a lower postprandial TMAO increase in occasional meat-eaters who consumed dietary fiber

This redundancy, combined with the fact that inhibition of hexokinase would confer severe side effects on normal, hexokinase-expressing tissues, probably accounts for their failure in clinical trials 192

Khunti K, Wolden ml, Thorsted BL, Andersen M, Davies MJ