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In the epilepsies, BBB function is degraded further by seizures as the disorder progresses: TJs (Rigau et al., 2007) and pericytes are lost (Milesi et al., 2014), efflux pumps, including the P-glycoprotein pump (P-gp), are degraded (Gil-Martins et al., 2020), and extravasation of blood components is facilitated (van Vliet et al., 2007

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