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We also found tanycytes and ependymal cells among the most affected cell types in all treatment groups in the hypothalamus, that is, cell types with privileged access to the third ventricle and which have previously been implicated in the food intake inhibitory effects of the GLP-1R agonist liraglutide 52

The mortality rates of male and female rats increased significantly from the 22nd or 23rd month, at the highest exposure, with a trend towards an increase at a level of 58 mg/m 3

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In rare cases, serious side effects such as pancreatitis (inflammation of the pancreas), gallbladder problems, severe abdominal pain, or signs of an allergic reaction can also require discontinuation

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