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With enhancement of target gene expression, it is proposed that NATs can increase the expression of the target gene through increasing the stability of the sense mRNA or euchromatin-associated epigenetic modifications [54]

The delay between glutathiones discovery in 1888 and its clinical use in the 1980s stems from three factors: poor oral bioavailability (the tripeptide was degraded in the gut before absorption), lack of understanding of its antioxidant mechanism until glutathione peroxidase was discovered in 1957, and institutional medicines slow adoption of redox biology as a treatment framework

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[DOI] [PubMed] [Google Scholar] 48.Trumble C