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Warning signs requiring urgent evaluation include persistent vomiting that prevents fluid intake, severe upper abdominal pain (particularly if radiating to the back), signs of hypoglycemia that don't resolve with carbohydrate intake, symptoms of dehydration (decreased urination, extreme thirst, dizziness), or any other concerning reactions

Additionally, preclinical research suggests GLP-1 agonists may inhibit nuclear factor-kappa B (NF-B) signaling, a central pathway in inflammatory responses