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The disease constitutes 5-10% of diabetes, and the disease is rising as a significant clinical and public health burden globally ( Unlike type 2 diabetes mellitus, for which many drug choices are available, the only available therapy for type 1 diabetes is insulin (Sodium Glucose cotransporters inhibitors are used as adjuvant therapy for uncontrolled T1DM and a body mass index (BMI) of 27 kg/m 2 )

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The copper ion within the complex is integral to its antioxidant and anti-inflammatory activities

The process of selecting papers, data collection as well as the quality assessment was performed independently by two authors (A.S., G.R.), and all disagreements were resolved by the discussion with the third author (R.O)

A cost of $6.74 was applied to each vitamin B12 prescription claim, as this was the mean cost of a vitamin B12 prescription among our sample