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Dalile B, Oudenhove LV, Vervliet B, Verbeke K

Designing HDAC-PROTACs: lessons learned so far

Here is what the evidence actually supports

The plasmid DNA encapsulated by LNPs demonstrated optimal characteristics for liver targeting, including particle size of approximately 100 nm, low polydispersity (approximately 0.2), neutral surface charges, and high DNA encapsulation efficiency (Supplementary Table 4) 25

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