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The next wave dual and triple agonists (GLP-1 + GIP + glucagon: tirzepatide, retatrutide, survodutide) are showing superior fat loss, better hepatic outcomes, and potentially preserved lean mass

It usually emerges from overlapping disturbances across muscle, liver, adipose tissue, gut hormone signalling, and brain insulin sensitivity

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Preservation of lean mass is particularly important for long-term metabolic stability, physical function, and weight maintenance